In the 17th century, philosopher Ren रे Descartes invented threads that connect different parts of the skin to the brain. Thus, when the flame touches the foot, a signal is sent to the brain. Subsequent research has shown that sensory neurons report changes in our environment.
In 1944, Joseph Erlanger And Herbert Gasser He received the Nobel Prize in Physiology or Medicine for his discovery of different types of sensory nerve fibers, which respond to different stimuli, for example, in response to painful and painless touch.
But a fundamental question remains. How are temperature and mechanical stimuli converted into electrical impulses in the nervous system?
The work done by Mr. Julius and Mr. Patapotian, for the first time, allows us to understand how heat, cold, and mechanical forces can trigger nerve impulses that allow us to become aware of the world around us and adapt to it.
Their work, the committee said, has already led to in-depth research for the development of treatments for a wide range of diseases, including chronic pain.
Who are the winners?
Dr. David Julius is a professor of physiology at the University of California, San Francisco. In the 1990’s, his research into the chemical compound capsaicin led scientists to understand the inflammation caused by pepper. Together with a team of co-workers, he created a library with millions of DNA fragments that are expressed in sensory neurons in response to pain, heat, and touch.
Ardem Patapotian is a molecular biologist and neuroscientist at Scripps Research in La Jolla, California, who “focuses on identifying and characterizing ion channels and other sensors that translate mechanical stimuli into chemical signals.” According to the Centre’s website.