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The third corona vaccination has been offered to risk groups in Germany for several weeks. The first studies now show which side effects vaccinated people will have to take into account.
On Monday, the European Medicines Agency gave Ema the green light for the so-called boostervaccination. An extra dose of the Covid-19 vaccines from biotech/Pfizer and Modern can people with severely debilitated? immune system not earlier than 28 days after the second dose. For people with normal immune systems aged 18 years and older, a booster vaccination may be considered at least six months after the second dose.
For this group, an Ema committee had data for the Biotechvaccine Comirnaty, who showed an increase in antibody levels in people between the ages of 18 and 55 with a booster dose about six months after the second dose. The Ema is still evaluating the data for a booster vaccination with the Moderna vaccine Spikevax.
About two weeks ago, the German Permanent Vaccination Commission (Stiko) made a third pike recommendation for some high-risk patients: those with immunodeficiencies and diseases treated with immunosuppressants.
The booster vaccination against the Coronavirus already offered in Germany. The guidelines for this differ per state.
General: The elderly (from 80 years, in Baden-Württemberg applies from 60 years), people who need care (at home or in their own household), people with disabilities in suitable facilities and immunocompromised people can be revaccinated.
Studies show the benefit of vaccination
A study of the Berliners Charity confirms the benefit of third party vaccination in these populations. The antibody concentration was measured in older people (mean age 82 years) compared to younger Charité employees (mean age 35 years). In the case of the elderly, four out of ten study participants were found to have no neutralizing antibodies to the Delta variant were more measurable. The youngsters still had more than 97 percent neutralizing antibodies. Both groups were vaccinated simultaneously and with the same vaccine (Biontech/Pfizer).
“Overall, these results suggest that the established two-dose vaccination schedule elicits fewer permanent immune responses in older people than in young adults,” the study preprint says. Data from Israel also shows that the third spade proves to be very effective.
Astrazeneca-vaccinated people can also refresh themselves
In addition to the risk groups, anyone who has previously only been vaccinated with Astrazeneca can receive a booster vaccination. “Even people who have received a full set of vaccinations with a vector vaccine will be offered a new vaccination in the interest of preventive health care,” explains the Federal Ministry of Health on its website. “The booster will receive a single dose of one of the two mRNA vaccines (Comirnaty from Biontech or Spikevax from Moderna) at least six months after completing the first set of vaccinations.”
The background to this is the knowledge that such a cross-vaccination improves immune protection. This means that priority group 1 medical and nursing staff are also entitled to revaccination if they have been vaccinated with Astrazeneca six months or more ago. ‘s second vector vaccine Johnson & Johnson was not yet available in the EU at the time.
Data app reveals side effects
The advantage of the third vaccination, in which only an mRNA vaccine is injected, seems undisputed for certain risk and priority groups. But what about possible? Effects from the booster?
There is now new data from the US. There is the smartphone tool “V-Safe”, which can be used to report side effects after the third kick. The US health authority CDC has now published a review of the data for the first time.
In the United States, about 2.2 million people have received the booster so far. More than 12,500 people shared their experiences in the app after the booster. They received their third vaccination an average of 182 days after the second. From August 12 to September 19, they reported the following most common side effects:
- 74.9 percent of patients reported a local injection site reaction (71 percent described this as mild pain)
- 56 percent felt tired and exhausted
- 43.4 percent complained of headaches.
It appears that the side effects of the third vaccination largely correspond to the experience already gained with the two previous vaccinations. The booster vaccination has no major side effects, but it does have a major advantage.
The Paul Ehrlich Institute also collects data on the side effects of the third-party vaccination. The SafeVac 2.0 app has been developed for this. You can find more information here.
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